殷杰：细胞表面受体的分子机制研究 ｜科学家请出镜
走进CIBR——
“科学家请出镜”
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CIBR
殷杰实验室
THE JIE YIN LAB
科学家介绍
About scientist
殷杰，毕业于中国科学院生物物理研究所，获得生物物理学博士学位，并在美国西南医学中心进行博士后研究。实验室研究细胞膜受体介导的神经信号传导的机制和结构基础，以及其神经生物学意义。目前，他的团队致力于揭示与精神病和神经退行性疾病相关的膜蛋白的分子机制。除了阐明其机制基础外，他们还旨在利用超大型虚拟对接库、DNA编码库筛选和酵母基因修饰纳米抗体筛选等技术，鉴定与脑部疾病相关关键膜蛋白的治疗性配体和抗体。
请介绍一下您的研究方向
Tell us about the research interests of your lab.
我们感兴趣的是细胞表面受体介导的神经信号的分子机制，这些细胞表面受体是重要的药物靶点，比如精神疾病和神经退行性疾病。具体来说，我们希望获得细胞表面受体与相互作用的配体和药物分子结合和激活的机理。
研究手段上我们主要用结构生物学阐明分子机制，辅之以计算化学、分子药理学和细胞生物学。除了阐明结构和机制之外，我们还利用超大型虚拟对接库筛选、基于细胞功能和分子结合试验的筛选和基于酵母的纳米抗体筛选，鉴定受体的配体和抗体，用于治疗用途或者作为神经药理学的研究工具。
We are interested in the molecular mechanisms of neuronal signaling mediated by cell surface receptors,which are important drug targets forpsychiatric and neurodegenerative diseases.Specifically, we aim to understand the binding and activation mechanismsof ligands and drug molecules with cell surface receptors.
Our research primarily utilizes structural biology to elucidate molecular mechanisms,supplemented by computational chemistry, molecular pharmacology, and cell biology.In addition to elucidating structures and mechanisms,we also employ strategies such as screening with ultra-large virtual docking libraries,assays based on cellular functions and molecular binding,and yeast-based nanobody screeningto identify ligands and antibodiesfor therapeutic purposes or as research tools in neuropharmacology.
短期和长期来看，您最希望解决的科学问题是什么？
What scientific problems do you want to solve most in the short and long term?
短期的科学问题是获得稳定的、状态特异和大量纯化的受体蛋白，用于小分子和抗体筛选以及三维结构解析，以阐明分子机制。
我们长期的挑战是，基于结构或者功能筛选鉴定优化，以获得选择性的配体小分子和抗体，一方面用于开发作为治疗用途，另一方面作为神经药理学的工具，理解大脑疾病的分子机制。
Short-term scientific problems areobtaining stable, state-specific, and highly purified receptor proteinsfor small molecule and antibody screening as well as for three-dimensional structure analysisto elucidate molecular mechanisms.
The long-term challenge isbased on structural or functional screening to identify and optimizeselective ligand molecules and antibodies,on the one hand for the development of therapeutic purposes,and on the other hand as tools in neuropharmacologyto understand the molecular mechanisms of brain disorders.
为什么选择加入脑中心？
Why choose CIBR?
我以前从分子机制上研究神经递质和激素激活的G蛋白偶联受体，这些G蛋白偶联受体是睡眠和帕金森疾病的重要靶点。我们从分子机制上解析了受体与药物或者临床药物分子的结合机理，为药物的合理设计打下基础。睡眠和帕金森症的药物很多，但是都有比较多的副作用，而且在一些情况下并不是对所有病人适用。一方面可能是药物设计本身不够完善，另一方面在于大脑疾病产生的复杂性。我希望学习和了解神经递质信号在细胞 环路以及更高层次是如何展开的，这是我选择CIBR的一个最重要的原因。
第二个是CIBR有着与国际接轨的体制，以及在国内和国际上独特的经费支撑体系，能够不用分心专注于自己感兴趣的研究。
第三个原因是，在面试的过程中感受到周围同事友好的氛围，有利于今后的学习和合作。
In the past, I studied the G-protein-coupled receptors activated by neurotransmitters and hormones at the molecular level.These G-protein-coupled receptors are important targets for sleep and Parkinson"s disease.We analyzed the binding mechanismbetween the receptors and drugs or clinical drug moleculesand lay the foundation for rational drug design.There are many drugs for sleep and Parkinson"s disease,but they often have significant side effectsand may not be effective for all patients.This may be due to insufficient drug designand the complexity of brain diseases.I hope to learn and understandhow neurotransmitter signaling unfolds at the cellular, circuit, and higher levels,which is the first reason why I chose to join CIBR.
The second reason is that CIBR has a system that is internationally recognizedand a unique support system domestically and internationally,allowing me to focus on my research without distractions.
The third reason is thatduring the interview process, I felt the friendliness of my potential colleagues,which will facilitate future learning and collaboration.
